At Novo Nordisk, we are working with the first ever oral protein formulation treatment for type 2 diabetes. Our objective within R&D, particularly within the Oral Protein Formulation Department, is to continue developing the next generation of oral protein treatments for type 2 diabetes as well as other chronic diseases. Formulation and analytical scientists and technicians play a fundamental role in this journey.
OPF is part of Novo
Nordisk’s R&D family. We develop oral products and their
manufacturing processes in our pilot plants, as well as analytical
methods. Our ambition is to continue to develop break-through
tablet products for chronic diseases, based on orally available
versions of pharmaceutical peptides and other molecules
Formulation employees play a critical role in developing and
manufacturing the next generation of innovative oral products for
pre-clinical and clinical trials, thereby paving the way for the
future manufacturing of these products.
Formulation technicians are responsible for the practical work performed in the lab, including the use of equipment for producing and analysing oral tablets. They are experts in the handling of equipment, such as tablet presses, roller compactors, blending equipmentbbut also smaller equipment used to characterise tablets and granules.
are responsible for developing the final drug product and
manufacturing process for solid dosage forms for clinical and
pre-clinical trials. A formulation scientist leads the design and
development of formulations and processes, scaling up for
manufacturing of batches for clinical and pre-clinical trials,
preparation of product development reports and support for all
necessary quality documentation and documentation for regulatory
Formulation scientists typically have a background in biochemistry,
pharmacy or other related areas. Experience within the formulation of
protein and peptides and also oral protein formulation, tablet
development or oral drug delivery are also characteristics of a
formulation scientist. A minimum of 2 years of industrial experience
or a PhD in a relevant field are often required.
Marie Darting is a formulation scientist working at our R&D site in Måløv, just outside Copenhagen. Find out more about her work as a formulation scientist, her perspective on development plans and the impact she feels her work can have on patients.
Our analytical research
employees are responsible for development and validation of
analytical methods for tablet process development and batch release.
They are also responsible for solid state characterisation including
particle characterisation and stability studies.
Analytical technicians are experts in the use of chromatographic equipment, such as HPLCs and UPLCs. An analytical technician conducts the analysis of experimental results and - together with the analytical scientists - determines which methods are best for each specific experiment.
Analytical scientists are responsible for developing analytical
methods, such as spectroscopy-based methods, chromatographic methods
or dissolution methods amongst others. Analytical scientists work in
close collaboration with the formulation employees and are responsible
for choosing the right analytical methods and providing them with the
right data and analysis to support decision making.
An analytical scientist typically has a background in pharmacy, engineering or other related fields within analytical sciences. In addition, they need to have experience with chromatographic equipment, be detail-oriented, data-driven and a good team player. Our colleagues are experienced within pharmaceutical drug development process, and often this is combined with experience within peptide or oral tablet production.
Erik Skibsted, Principal Scientist within CMC development talks about his work as an analytical scientist and what it takes to be successful. Hear about his role in developing the first oral protein treatment for type 2 diabetes, and discover your opportunities for getting involved.