Long-acting CCK analogue

PLEASE NOTE THAT THIS COMPOUND CAN ONLY BE USED FOR IN VITRO STUDIES (NOT IN VIVO)

Cholecystokinin (CCK) is a gut and brain peptide hormone that plays an important role in the regulation of energy balance. CCK binds to two G-protein-coupled receptors, the CCK 1 receptor (CCK-1R) and the CCK 2 receptor (CCK-2R). Both receptors are found in the gastrointestinal tract and in the central nervous system. Activation of CCK-1R has effects on appetite regulation and a number of other effects (gallbladder contraction, pancreatic enzyme secretion, delay of gastric emptying).  The CCK-2R has effects on anxiety, pain, attention, memory and the stimulation of gastric acid by gastrin is mediated by the activation of the CCK-2R.  

NN0368-0056 is a long-acting and highly selective CCK-1R analogue. In the Senfuss et al. 2019 reference listed in the reference section, NNC0368-0056 is compound 10.

Due to unexpected finding in vivo (see the Nyborg et al. 2020 reference listed in the reference section), NNC0368-0056 can only be used for in vitro studies.