Long-acting amylin analogue

Amylin is a 37-amino acid peptide that is stored in pancreatic beta cells and co-secreted with insulin. Amylin is an important regulator of energy metabolism and belongs to the calcitonin peptide family. Amylin acts via amylin receptors have mainly been identified in the hind brain. The amylin receptor consists of a calcitonin receptor (several splice variants) which heterodimerizes with one of three receptor activity-modifying protein (RAMP) splice variants thus generating many possible amylin receptor subtypes with different pharmacological properties.

NNC0174-0839 is a dual-acting amylin analogue with agonistic effects on the amylin receptor as well as the calcitonin receptor. NNC0174-0839 have been designed to be long-acting in vivo . The main mechanism for the extended half-life is albumin binding.