InsR peptide agonist (S597)

Insulin binds to the insulin receptor (InsR), which exists in two alternatively spliced isoforms, InsR-A and InsR-B. The insulin receptor belongs to the same family of receptor tyrosine kinases as the IGF1 receptor (IGF1R) and insulin is therefore also able to bind to the IGF1R albeit with considerably lower affinity as compared to the InsR.

NNC0069-0597 (also known as S597) is a single chain peptide consisting of 31 amino acids, which has been shown to be a specific InsR agonist. The affinity of S597 for the human insulin receptor is comparable to that of human insulin, however, the signalling and consequently also cellular responses elicited by of S597 is different from that of human insulin. S597 can be used in both in vitro and in vivo experiments.