Type 1 diabetes

Since the discovery of insulin, we have been working on improving treatment for people living with diabetes. We continue to focus on our core capabilities across the spectrum of the disease to meet patients' unfulfilled needs. Some people with type 1 diabetes cannot control their blood glucose level and consequently struggle to lead a daily life without potentially life-threatening and disabling hypo- and hyperglycaemic events as well as diabetes-related complications.

 

Improving and innovating treatments for better blood glucose control

Type 1 diabetes is caused by the autoimmune destruction of insulin-producing beta cells. Our researchers are working on an immunometabolic combination therapy, which they believe, in the long term, can stop the immune system attacking the beta cells and stabilise the surviving beta cells.

In addition to beta cell research, we continue to investigate insulin and other molecules for longer-acting and more efficient treatments to help defeat diabetes. 

 

   

R&D centre in Seattle

In 2012, Novo Nordisk launched a type 1 diabetes R&D centre in Seattle, Washington, USA as part of Novo Nordisk's Diabetes Research Unit. The unique concept behind the centre is to combine basic research and early proof-of-concept trials under one umbrella.

Researchers at the centre have a mandate to pursue a translational research approach to finding new antigen-based immunological and vaccine treatment advances for type 1 diabetes via both in-house and external public–private collaborations.

  

 

  

In the pipeline

  • Injections once weekly or even less often
  • Oral insulins and GLP-1
  • Insulins targeting the liver
  • Stem cell research and beta cell regeneration
  • Combination therapies

Click here for details

 

 

 

Type 1 diabetes clinical trials

Every year, we conduct clinical trials in more than 50 countries. To ensure best practice, skills and knowledge in the development of therapies, we work with the world's leading academic centres and preferred industrial partners. An overview of these activities worldwide can be found on our clinical trials website.