full announcement

17 May 2017 16:30 CET

Early response to Saxenda® resulted in weight maintenance and additional weight loss over 56 weeks

Porto, Portugal, 17 May 2017 - Today, results from a post-hoc analysis of data from the SCALE Maintenance trial were presented at the 24th European Congress on Obesity (ECO) 2017. In the trial, adults who lost at least 5% of their initial weight during a low- calorie run-in period were randomised to receive Saxenda® (liraglutide 3 mg) or placebo. After 16 weeks of treatment with Saxenda®, participants who lost an additional 5% or more of their body weight (defined as 'early responders') were more likely to maintain weight loss and achieve greater additional weight loss over 56 weeks, compared with people losing less than 5% body weight after 16 weeks of Saxenda® treatment ('early non-responders').1

"In the obesity specialist setting, low-calorie diets combined with increased physical activity are commonly used to induce an initial weight loss in people with obesity. However, when the initial weight loss reaches a plateau and patients enter the 'weight maintenance phase' with less stringent caloric restriction, we often see that many experience weight regain," said Dr Sean Wharton, medical director at the Wharton Medical Clinic, Ontario and SCALE clinical trial investigator. "As a consequence, pharmacotherapy can be used to help people with obesity in maintaining the weight loss that has already been achieved by a low-calorie diet and increased physical activity. These data are very encouraging to clinicians in this specialist setting, because they show that early responders to Saxenda® are able to both maintain and achieve additional weight loss".

Further information

Katrine Sperling +45 4442 6718
Åsa Josefsson +45 3079 7708
Peter Hugreffe Ankersen +45 3075 9085
Anders Mikkelsen +45 3079 4461
Hanna Ögren +45 3079 8519
Kasper Veje (US) +1 609 235 8567


Read the full release including references

1. Wharton S, Jacobsen P, Arrone L. Early responders to liraglutide 3.0 mg as adjunct to diet and excercise from the SCALE Maintenance trial. Oral presentation number RS3:3. ECO. 2017